Announcing gnomAD v4!

Today, we are thrilled to announce the release of gnomAD v4, which includes data from 807,103 total individuals.

This release is nearly 5x larger than the combined v2/v3 releases and consists of two callsets: exome sequencing data from 730,947 individuals, including 416,555 individuals from the UK Biobank, and genome sequencing data from 76,215 individuals. Both callsets within v4 were aligned to build GRCh38 of the human reference genome, critically enabling and empowering improved gene constraint estimates in GRCh38.