Hi, i’ve noticed that for most of the variants the spliceai_ds_max score listed in the v4 VCF files doesn’t seem to match the maximum delta score as seen in the spliceailookup tool. For example the variant chr21-10649707-C-A has spliceai_ds_max=0.240000 listed in the VCF, but when you look at the scores on spliceailookup (SpliceAI Lookup) the maximum delta shown in 0.86. Has anyone else noticed this/ found an explanation? I’m not sure if it’s just due to some difference in how the spliceai_ds_max scores were generated or if there was an error when they were generated. Pangolin scores do seem to match.
1 Like