Hello, I am now finding variants associated with cancer. Dataset gnomAD v3.1.2 shows 76,156 samples. I have two questions to get your helps. 1) Dataset gnomAD v3.1.2 (non-cancer) shows 74,023 samples. Subtraction between 76,156 and 74,023 shows 2133. Simply, Are 2133 variants associated with cancer? Is it right for me to understand? Please give me your suggestions. 2) if it is correct. I would like to know types of cancers, age, sex information. Is it possible to get the information? Please let me know your suggestions and any missing for me.
Hello,
Thank you for your questions! If I understand correctly, you’re asking about the numbers in the context of samples, not variants. To clarify, gnomAD serves as an aggregated database for allele frequencies (AF) and other variant-related features, but we do not associate any specific variants with cancer or other phenotypes.
Regarding your second question, due to various reasons such as consent and data usage restrictions, gnomAD does not include or share detailed phenotype information. However, we can provide limited information for some cohorts, such as the last known age (in 5-year bins, when available) and chromosomal sex.
I hope this helps clarify! Please feel free to reach out with any additional questions.