How to download the information on pLI for all genes?

Are there any tutorials on how to handle Gnomad data programatically? I’d like to do an exhaustive search rather than just for a few genes.
Thank you!

Hi Emma,

If you want constraint scores (like pLI) for all genes, you can get them from our “Downloads” page. You can search for the “constraint” sub-sections under our gnomaD v2 or gnomAD v4 headings to find the files. Here is one link: