GnomAD v2.1.1 Regional missense constraint file is incomplete

Constraint
1

for some work in ACMG classfication ，i need get the Z-score and the oe of everygene/ Regional missense constraint (in v2.1.1). i download two files as follow:

  • Regional missense constraint TSV (transcripts with RMC)
    Download from [ Microsoft
  • Regional missense constraint TSV (transcripts without RMC)
    Download from Microsoft

I found that the genes in these two files are complementary, and i can’t got the z-score for the gene in gnomAD_v2.1.1_transcripts_without_rmc.tsv, i didn’t found a file contain the z-score for all genes in v2.1.1. is there some good way to get the z-score for all the gene (better than search all miss gene one by one)

2

The regional missense constraint downloadable files do not contain information about gene-level missense constraint. Gene-level missense constraint, including missense observed/expected ratio and Z-scores, can be found in the gene constraint downloadable files.

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