I was wondering if it would be possible to show the frames of exons (phases) in gnomAD instead of just showing the transcripts and their exons?
The exon frames become important when discussing the pathogenicity of variants and also discussing therapeutic options.
When there is an exon deletion or a canonical splice site variant that is leading to exon skipping, it depends whether the exon is in-frame (exon length divisible by three) or out-of-frame, the latter causing a frameshift but the former is an in-frame deletion and thus not necessarily pathogenic.
Further, knowing which exons are in-frame will help decide whether exons can safely be removed from transcripts for therapeutic approaches.
Ensembl is providing information on exon frames and UCSC Genome browser has started showing frames with a mouse-over, it would be great if other webtools, such as gnomAD, would start showing this information, too.