gnomAD v4 - bottleneck populations?

Hi All,

Was wondering if anyone has any insight on what populations are excluded from the FAF in gnomAD v4 due to being bottleneck populations like AJ/Other (Now Remaing)/FIN. Do we know if the Middle Eastern is considered a bottleneck population?
Thanks!

Hi @Katiemay8199,

Thank you for you inquiry! This led us to discover we erroneously left the Middle Eastern genetic ancestry group out of our FAF and grpmax calculations in v4.0.

In previous releases, we removed the Middle Eastern genetic ancestry group from FAF as we did not have enough samples to consider them. However, we now enough samples in v4 and we will be adding them to FAF and grpmax calculations in our v4.1 release. The genetic ancestry groups that will be excluded in v4.1 FAF and grpmax calculations are “asj”, “fin”, “ami”(genomes only), and “remaining”.

Thanks again!
Mike

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Oh wow! Good to know! Thank you so much! Look forward to seeing this in your v4.1 release!

Thank you for replying and the update. Much appreciated!

-Katie