Hi, I would like to confirm if gnomad v4.1 uses the genome build from UCSC - https://hgdownload.soe.ucsc.edu/goldenPath/hg38/bigZips/ or from broad’s resource bundle. Is there a difference?
I really appreciate your time.
Thanks!
gnomAD uses reference genome build GRCh38 as specified by Hail, which pulls reference genome information from the GATK resource bundle. Questions about differences between this reference build and UCSC’s version are likely better directed to either GATK or UCSC.