Hello,
We are doing an ancestry study and we only need non-pathological individuals. How can we distinguish them from pathological ones? How can we download only the vcf of healthy ones?
Thank you
From our About page:
The gnomAD database is composed of exome and genome sequences from around the world. We have removed cohorts that were recruited for pediatric disease, except for a small number of diverse cohorts where we have included unaffected relatives. As such, the gnomAD resource should serve as useful reference sets of allele frequencies for severe pediatric disease studies - however, note that some individuals with severe disease may still be included in the data sets such as biobanks, albeit likely at a frequency equivalent to or lower than that seen in the general population.
A list of projects that contributed data to gnomAD is also available on the About page, and a table containing the percent of individuals with certain common diseases can be found here.
If you need to filter data based on phenotype, perhaps you could consider applying for access to the UK Biobank or All of Us datasets.