Hello! I would like to know if there is a plan to extend the gnomAD coocurrence feature to include non-coding regions? Also, will it ever be possible to input more than 2 variants. Thanks! - Joe Norman
Hi Joe,
We already include some noncoding variants in the flanking intronic regions, specifically variants from position −1 to −3 in acceptor sites and +1 to +8 in donor sites and variants in the 5′ and 3’ UTRs. Expanding beyond that is being considered, but massively scales up the analysis. Do you have a use case for where this would be helpful?
As for searching for more than two variants, we are also considering it but can’t promise it as the more variants you can enter into a tool like this, the more identifiable samples get.
-Kaitlin