Different HGVSp of canonical transcript for ARHGEF18 (gnomAD v2.1.1)

Browser
1

When I searched for a variant (19-7509332-G-A) in gnomAD v2.1.1, I found that the canonical transcript’s HGVSp for this variant is p.Val347Ile.

However, When I searched for the same variant on ClinVar again, the HGVSp of the canonical transcript is reported as p.Val535Ile, which differs from p.Val347Ile (on gnomAD).

Could you please check this discrepancy for the mentioned variant?

Thank you.

2

This variant in gnomAD v2.1.1 was annotated in GRCh37 and Gencode v19, if you click on liftover on that variant page, you will find it in gnomAD v4.1 (annotated to GRCh38/Gencode v39), its HGVSp is p.Val535Ile.

3

@Qin Yes, I know this variant as annotated in GRCh37.
But I can’t understand why HGVSp is p.Val347Ile which differs from p.Val535Ile (on gnomAD v4.1).

Could you explain this situation?