# C4B variant, please help!

**URL:** <https://discuss.gnomad.broadinstitute.org/t/c4b-variant-please-help/480>\
**Category:** General\
**Created:** [October 29, 2024, 11:48pm UTC](https://discuss.gnomad.broadinstitute.org/t/c4b-variant-please-help/480 "2024-10-29T23:48:22Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![Verelen\_Oprea](https://sea2.discourse-cdn.com/flex016/user_avatar/discuss.gnomad.broadinstitute.org/verelen_oprea/32/189_2.png) [@Verelen\_Oprea](https://discuss.gnomad.broadinstitute.org/u/Verelen_Oprea)\
**Post date:** [October 29, 2024, 11:48pm UTC](https://discuss.gnomad.broadinstitute.org/t/c4b-variant-please-help/480/1 "2024-10-29T23:48:22Z")

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C4B: c.3735G\>A  
Could I please get help into finding if this variant is considered bening or not? 4 algorithm indicated that it indicated the introduction of a new splice acceptor site.  
Could not find research.  
Please help

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**Author:** ![kchao](https://sea2.discourse-cdn.com/flex016/user_avatar/discuss.gnomad.broadinstitute.org/kchao/32/6_2.png) [@kchao](https://discuss.gnomad.broadinstitute.org/u/kchao)\
**Post date:** [February 20, 2025, 8:44pm UTC](https://discuss.gnomad.broadinstitute.org/t/c4b-variant-please-help/480/2 "2025-02-20T20:44:47Z")

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Unfortunately, variant classification and interpretation are out of the scope of our work. Perhaps another user could help with this question?